Pseudomonas infections drive persistent lung inflammation after modulators
Infected organs exhibit marked region-to region heterogeneity, and it is unknown how different regions respond to treatment.
The researchers used multi-region bronchoscopy in people with cystic fibrosis (CF) to determine how lung segments differing in Pseudomonas (Pa) burden, inflammation, and damage respond to a groundbreaking drug treatment targeting the CF physiological defect.
The researchers fond an “all-or-none” infection clearance response: the most-diseased segments clear if any other lung segment in that person clears, and the least-diseased segments remain infected if others in that person do.
Also, neutrophilic inflammation completely resolves where Pa clears but remains elevated where Pa persists.
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(25)00281-1
